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Viral Diseases of Nonhuman Primates

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As a result, it includes the evidence quality rating for many types of studies, Table 2Questions addressed by liver experts in the 20National STRENGTH OF RECOMMENDATION: A (strong) (depending on the medication used). with a request that the patient return at a later date for an additional medical.

Metrics details. Regenerative medicine relying on cell and gene therapies is one of the most promising approaches to repair tissues. The mechanisms by which MSC exert these actions include the release of biomolecules with anti-inflammatory, immunomodulating, anti-fibrogenic, and trophic functions. While we expect the spectra of these molecules with a therapeutic profile to progressively expand, several human pathological conditions have begun to benefit from these biomolecule-delivering properties.

In addition, MSC have also been proposed to vehicle genes capable of further empowering these functions. This review deals with the therapeutic properties of MSC, focusing on their ability to secrete naturally produced or gene-induced factors that can be used in the treatment of kidney, lung, heart, liver, pancreas, nervous system, and skeletal diseases. We specifically focus on the different modalities by which MSC can exert these functions. We aim to provide an updated understanding of these paracrine mechanisms as a prerequisite to broadening the therapeutic potential and clinical impact of MSC.

Peer Review reports. MSC, historically isolated from bone marrow BM , emerged in the biomedical field for their proliferative capacity and the potential to generate skeletal-related tissues [ 4 ]. Research therefore originally focused on their ability to differentiate into committed cell types within injured areas. More recently, evidence suggests that other MSC-related mechanisms, such as secretion of cytokines or release of microvesicles MV , may play a significant role, by promoting the stimulation of endogenous cells, the inhibition of apoptosis, neovascularization, and anti-inflammatory responses [ 5 — 7 ].

Early in vivo evidence suggested that MSC may also induce tolerance [ 8 ].

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Multiplex Biomarker Techniques

Chikungunya virus CHIKV and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. The immune mechanisms, which control viral multiplication and dissemination, are not yet known. E2EP3 is located at the N-terminus of the E2 glycoprotein and prominently exposed on the viral envelope. Screening of E2EP3 across different patient cohorts and in non-human primates demonstrated the value of this epitope as a good serology detection marker for CHIKV infection already at an early stage.

Therefore, it may represent a major public health problem with severe social and economic impact. The virus contains a positive-sense, single-stranded, non-segmented ribonucleic acid RNA genome of approximately

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